AustralieFrV1, Main, Exploration, bibRecord, 002253

Central Nervous System Involvement by Multiple Myeloma: a Multi-Institutional Retrospective Study of 172 Patients in daily clinical practice

Identifieur interne : 002253 ( Main/Exploration ); précédent : 002252; suivant : 002254

Central Nervous System Involvement by Multiple Myeloma: a Multi-Institutional Retrospective Study of 172 Patients in daily clinical practice

Auteurs : Artur Jurczyszyn [Pologne] ; Norbert Grzasko [Pologne] ; Alessandro Gozzetti [Italie] ; Jacek Czepiel [Pologne] ; Alfonso Cerase [Italie] ; Vania Hungria [Brésil] ; Edvan Crusoe [Brésil] ; Ana Luiza Miranda Silva Diaz [Brésil] ; Ravi Vij [États-Unis] ; Mark A. Fiala [États-Unis] ; Jo Caers [Belgique] ; Leo Rasche [Allemagne] ; Ajay K. Nooka [États-Unis] ; Sagar Lonial [États-Unis] ; David H. Vesole [États-Unis] ; Sandhya Philip [États-Unis] ; Shane Gangatharan [Australie] ; Agnieszka Druzd-Sitek [Pologne] ; Jan Walewski [Pologne] ; Alessandro Corso [Italie] ; Federica Cocito [Italie] ; Marie-Christine M. Vekemans [Belgique] ; Erden Atilla [Turquie] ; Meral Beksac [Turquie] ; Xavier Leleu [France] ; Julio Davila [Espagne] ; Ashraf Badros [États-Unis] ; Ekta Aneja [États-Unis] ; Niels Abildgaard [Danemark] ; Efstathios Kastritis [Grèce] ; Dorotea Fantl [Argentine] ; Natalia Schutz [Argentine] ; Tomas Pika [République tchèque] ; Aleksandra Butrym [Pologne] ; Magdalena Olszewska-Szopa [Pologne] ; Lidia Usnarska-Zubkiewicz [Pologne] ; Saad Usmani [États-Unis] ; Hareth Nahi [Suède] ; Chor S. Chim [Hong Kong] ; Chaim Shustik [Canada] ; Krzysztof Madry [Pologne] ; Suzanne Lentzsch [États-Unis] ; Alina Swiderska [Pologne] ; Grzegorz Helbig [Pologne] ; Renata Guzicka-Kazimierczak [Pologne] ; Nikoletta Lendvai [États-Unis] ; Anders Waage [Norvège] ; Kristian T. Andersen [Danemark] ; Hirokazu Murakami [Japon] ; Sonja Zweegman [Pays-Bas] ; Jorge J. Castillo [États-Unis]

Source :

American journal of hematology [ 0361-8609 ] ; 2016.

RBID : PMC:5502095

Descripteurs français

KwdFr :
- Aberrations des chromosomes, Adulte, Adulte d'âge moyen, Analyse de survie, Antinéoplasiques (usage thérapeutique), Association thérapeutique, Femelle, Humains, Myélome multiple (), Myélome multiple (anatomopathologie), Myélome multiple (mortalité), Mâle, Pronostic, Radiothérapie, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Taux de survie, Tumeurs du système nerveux central (), Tumeurs du système nerveux central (diagnostic), Tumeurs du système nerveux central (mortalité), Tumeurs du système nerveux central (secondaire), Études rétrospectives.
MESH :
- anatomopathologie : Myélome multiple.
- diagnostic : Tumeurs du système nerveux central.
- mortalité : Myélome multiple, Tumeurs du système nerveux central.
- secondaire : Tumeurs du système nerveux central.
- usage thérapeutique : Antinéoplasiques.
- Aberrations des chromosomes, Adulte, Adulte d'âge moyen, Analyse de survie, Association thérapeutique, Femelle, Humains, Myélome multiple, Mâle, Pronostic, Radiothérapie, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Taux de survie, Tumeurs du système nerveux central, Études rétrospectives.

English descriptors

KwdEn :
- Adult, Aged, Aged, 80 and over, Antineoplastic Agents (therapeutic use), Central Nervous System Neoplasms (diagnosis), Central Nervous System Neoplasms (mortality), Central Nervous System Neoplasms (secondary), Central Nervous System Neoplasms (therapy), Chromosome Aberrations, Combined Modality Therapy, Female, Humans, Male, Middle Aged, Multiple Myeloma (complications), Multiple Myeloma (mortality), Multiple Myeloma (pathology), Multiple Myeloma (therapy), Prognosis, Radiotherapy, Retrospective Studies, Survival Analysis, Survival Rate, Treatment Outcome.
MESH :
- chemical , therapeutic use : Antineoplastic Agents.
- complications : Multiple Myeloma.
- diagnosis : Central Nervous System Neoplasms.
- mortality : Central Nervous System Neoplasms, Multiple Myeloma.
- pathology : Multiple Myeloma.
- secondary : Central Nervous System Neoplasms.
- therapy : Central Nervous System Neoplasms, Multiple Myeloma.
- Adult, Aged, Aged, 80 and over, Chromosome Aberrations, Combined Modality Therapy, Female, Humans, Male, Middle Aged, Prognosis, Radiotherapy, Retrospective Studies, Survival Analysis, Survival Rate, Treatment Outcome.

Abstract

The multicenter retrospective study conducted in 38 centers from 20 countries including 172 adult patients with CNS MM aimed to describe the clinical and pathological characteristics and outcomes of patients with multiple myeloma (MM) involving the central nervous system (CNS). Univariate and multivariate analyses were performed to identify prognostic factors for survival. The median time from MM diagnosis to CNS MM diagnosis was 3 years. Thirty-eight patients (22%) were diagnosed with CNS involvement at the time of initial MM diagnosis and 134 (78%) at relapse/progression. Upon diagnosis of CNS MM, 97% patients received initial therapy for CNS disease, of which 76% received systemic therapy, 36% radiotherapy and 32% intrathecal therapy. After a median follow-up of 3.5 years, the median overall survival (OS) from the onset of CNS involvement for the entire group was 7 months. Untreated and treated patients had median OS of 2 and 8 months, respectively (p<0.001). At least one previous line of therapy for MM before the diagnosis of CNS disease and >1 cytogenetic abnormality detected by FISH were independently associated with worse OS. The median OS for patients with 0, 1 and 2 of these risk factors were 25 months, 5.5 months and 2 months, respectively (p<0.001). Neurological manifestations, not considered chemotherapy-related, observed at any time after initial diagnosis of MM should raise a suspicion of CNS involvement. Although prognosis is generally poor, the survival of previously untreated patients and patients with favorable cytogenetic profile might be prolonged due to systemic treatment and/or radiotherapy.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502095

DOI: 10.1002/ajh.24351
PubMed: 26955792
PubMed Central: 5502095

Affiliations:

Le document en format XML

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<author><name sortKey="Davila, Julio" sort="Davila, Julio" uniqKey="Davila J" first="Julio" last="Davila">Julio Davila</name>
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<author><name sortKey="Badros, Ashraf" sort="Badros, Ashraf" uniqKey="Badros A" first="Ashraf" last="Badros">Ashraf Badros</name>
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</affiliation>
</author>
<author><name sortKey="Abildgaard, Niels" sort="Abildgaard, Niels" uniqKey="Abildgaard N" first="Niels" last="Abildgaard">Niels Abildgaard</name>
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<author><name sortKey="Kastritis, Efstathios" sort="Kastritis, Efstathios" uniqKey="Kastritis E" first="Efstathios" last="Kastritis">Efstathios Kastritis</name>
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<country xml:lang="fr">Grèce</country>
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</placeName>
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<author><name sortKey="Fantl, Dorotea" sort="Fantl, Dorotea" uniqKey="Fantl D" first="Dorotea" last="Fantl">Dorotea Fantl</name>
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<author><name sortKey="Schutz, Natalia" sort="Schutz, Natalia" uniqKey="Schutz N" first="Natalia" last="Schutz">Natalia Schutz</name>
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<author><name sortKey="Pika, Tomas" sort="Pika, Tomas" uniqKey="Pika T" first="Tomas" last="Pika">Tomas Pika</name>
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<author><name sortKey="Butrym, Aleksandra" sort="Butrym, Aleksandra" uniqKey="Butrym A" first="Aleksandra" last="Butrym">Aleksandra Butrym</name>
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<author><name sortKey="Olszewska Szopa, Magdalena" sort="Olszewska Szopa, Magdalena" uniqKey="Olszewska Szopa M" first="Magdalena" last="Olszewska-Szopa">Magdalena Olszewska-Szopa</name>
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</affiliation>
</author>
<author><name sortKey="Chim, Chor S" sort="Chim, Chor S" uniqKey="Chim C" first="Chor S" last="Chim">Chor S. Chim</name>
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<author><name sortKey="Shustik, Chaim" sort="Shustik, Chaim" uniqKey="Shustik C" first="Chaim" last="Shustik">Chaim Shustik</name>
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<region type="state">Québec</region>
<settlement type="city">Montréal</settlement>
</placeName>
<orgName type="university">Université McGill</orgName>
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</author>
<author><name sortKey="Madry, Krzysztof" sort="Madry, Krzysztof" uniqKey="Madry K" first="Krzysztof" last="Madry">Krzysztof Madry</name>
<affiliation wicri:level="1"><nlm:aff id="A28">Medical University, Warsaw, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Medical University, Warsaw</wicri:regionArea>
<wicri:noRegion>Warsaw</wicri:noRegion>
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</author>
<author><name sortKey="Lentzsch, Suzanne" sort="Lentzsch, Suzanne" uniqKey="Lentzsch S" first="Suzanne" last="Lentzsch">Suzanne Lentzsch</name>
<affiliation wicri:level="2"><nlm:aff id="A29">Columbia University Medical Center, New York, New York, USA</nlm:aff>
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<wicri:regionArea>Columbia University Medical Center, New York, New York</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Swiderska, Alina" sort="Swiderska, Alina" uniqKey="Swiderska A" first="Alina" last="Swiderska">Alina Swiderska</name>
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<wicri:regionArea>Provincial Hospital, Zielona Gora</wicri:regionArea>
<wicri:noRegion>Zielona Gora</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Helbig, Grzegorz" sort="Helbig, Grzegorz" uniqKey="Helbig G" first="Grzegorz" last="Helbig">Grzegorz Helbig</name>
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<wicri:noRegion>Szczecin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lendvai, Nikoletta" sort="Lendvai, Nikoletta" uniqKey="Lendvai N" first="Nikoletta" last="Lendvai">Nikoletta Lendvai</name>
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</author>
<author><name sortKey="Waage, Anders" sort="Waage, Anders" uniqKey="Waage A" first="Anders" last="Waage">Anders Waage</name>
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<country xml:lang="fr">Norvège</country>
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</author>
<author><name sortKey="Andersen, Kristian T" sort="Andersen, Kristian T" uniqKey="Andersen K" first="Kristian T." last="Andersen">Kristian T. Andersen</name>
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<country xml:lang="fr">Danemark</country>
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<author><name sortKey="Murakami, Hirokazu" sort="Murakami, Hirokazu" uniqKey="Murakami H" first="Hirokazu" last="Murakami">Hirokazu Murakami</name>
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<country xml:lang="fr">Japon</country>
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<author><name sortKey="Zweegman, Sonja" sort="Zweegman, Sonja" uniqKey="Zweegman S" first="Sonja" last="Zweegman">Sonja Zweegman</name>
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<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>VU University Medical Center, Amsterdam</wicri:regionArea>
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<author><name sortKey="Castillo, Jorge J" sort="Castillo, Jorge J" uniqKey="Castillo J" first="Jorge J." last="Castillo">Jorge J. Castillo</name>
<affiliation wicri:level="2"><nlm:aff id="A38">Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA</nlm:aff>
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<wicri:regionArea>Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Central Nervous System Involvement by Multiple Myeloma: a Multi-Institutional Retrospective Study of 172 Patients in daily clinical practice</title>
<author><name sortKey="Jurczyszyn, Artur" sort="Jurczyszyn, Artur" uniqKey="Jurczyszyn A" first="Artur" last="Jurczyszyn">Artur Jurczyszyn</name>
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</author>
<author><name sortKey="Grzasko, Norbert" sort="Grzasko, Norbert" uniqKey="Grzasko N" first="Norbert" last="Grzasko">Norbert Grzasko</name>
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<wicri:regionArea>Medical University of Lublin, Department of Hematooncology and Bone Marrow Transplantation, Lublin, Poland; St. John’s Cancer Center, Department of Hematology, Lublin</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Gozzetti, Alessandro" sort="Gozzetti, Alessandro" uniqKey="Gozzetti A" first="Alessandro" last="Gozzetti">Alessandro Gozzetti</name>
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<country xml:lang="fr">Italie</country>
<wicri:regionArea>Azienda Ospedaliera Universitaria Senese, Siena</wicri:regionArea>
<wicri:noRegion>Siena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Czepiel, Jacek" sort="Czepiel, Jacek" uniqKey="Czepiel J" first="Jacek" last="Czepiel">Jacek Czepiel</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Jagiellonian University Medical College, Cracow, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Jagiellonian University Medical College, Cracow</wicri:regionArea>
<wicri:noRegion>Cracow</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cerase, Alfonso" sort="Cerase, Alfonso" uniqKey="Cerase A" first="Alfonso" last="Cerase">Alfonso Cerase</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Azienda Ospedaliera Universitaria Senese, Siena, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Azienda Ospedaliera Universitaria Senese, Siena</wicri:regionArea>
<wicri:noRegion>Siena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hungria, Vania" sort="Hungria, Vania" uniqKey="Hungria V" first="Vania" last="Hungria">Vania Hungria</name>
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<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Santa Casa Medical School, Sao Paulo</wicri:regionArea>
<placeName><settlement type="city">São Paulo</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Crusoe, Edvan" sort="Crusoe, Edvan" uniqKey="Crusoe E" first="Edvan" last="Crusoe">Edvan Crusoe</name>
<affiliation wicri:level="3"><nlm:aff id="A4">Santa Casa Medical School, Sao Paulo, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Santa Casa Medical School, Sao Paulo</wicri:regionArea>
<placeName><settlement type="city">São Paulo</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Diaz, Ana Luiza Miranda Silva" sort="Diaz, Ana Luiza Miranda Silva" uniqKey="Diaz A" first="Ana Luiza Miranda Silva" last="Diaz">Ana Luiza Miranda Silva Diaz</name>
<affiliation wicri:level="3"><nlm:aff id="A4">Santa Casa Medical School, Sao Paulo, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Santa Casa Medical School, Sao Paulo</wicri:regionArea>
<placeName><settlement type="city">São Paulo</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Vij, Ravi" sort="Vij, Ravi" uniqKey="Vij R" first="Ravi" last="Vij">Ravi Vij</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
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<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
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</author>
<author><name sortKey="Fiala, Mark A" sort="Fiala, Mark A" uniqKey="Fiala M" first="Mark A." last="Fiala">Mark A. Fiala</name>
<affiliation wicri:level="4"><nlm:aff id="A5">Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
</author>
<author><name sortKey="Caers, Jo" sort="Caers, Jo" uniqKey="Caers J" first="Jo" last="Caers">Jo Caers</name>
<affiliation wicri:level="1"><nlm:aff id="A6">Centre Hospitalier Universitaire de Liege, Liege, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Centre Hospitalier Universitaire de Liege, Liege</wicri:regionArea>
<wicri:noRegion>Liege</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rasche, Leo" sort="Rasche, Leo" uniqKey="Rasche L" first="Leo" last="Rasche">Leo Rasche</name>
<affiliation wicri:level="1"><nlm:aff id="A7">University Hospital Wuerzburg, Wuerzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University Hospital Wuerzburg, Wuerzburg</wicri:regionArea>
<wicri:noRegion>Wuerzburg</wicri:noRegion>
<wicri:noRegion>Wuerzburg</wicri:noRegion>
<wicri:noRegion>Wuerzburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nooka, Ajay K" sort="Nooka, Ajay K" uniqKey="Nooka A" first="Ajay K." last="Nooka">Ajay K. Nooka</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Winship Cancer Institute, Emory University, Atlanta, Georgia, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Winship Cancer Institute, Emory University, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lonial, Sagar" sort="Lonial, Sagar" uniqKey="Lonial S" first="Sagar" last="Lonial">Sagar Lonial</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Winship Cancer Institute, Emory University, Atlanta, Georgia, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Winship Cancer Institute, Emory University, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vesole, David H" sort="Vesole, David H" uniqKey="Vesole D" first="David H." last="Vesole">David H. Vesole</name>
<affiliation wicri:level="2"><nlm:aff id="A9">John Theurer Cancer Center at Hackensack UMC, New Jersey, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>John Theurer Cancer Center at Hackensack UMC, New Jersey</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Philip, Sandhya" sort="Philip, Sandhya" uniqKey="Philip S" first="Sandhya" last="Philip">Sandhya Philip</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>John Theurer Cancer Center at Hackensack UMC, New Jersey</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gangatharan, Shane" sort="Gangatharan, Shane" uniqKey="Gangatharan S" first="Shane" last="Gangatharan">Shane Gangatharan</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>Fremantle Hospital, Fremantle</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Druzd Sitek, Agnieszka" sort="Druzd Sitek, Agnieszka" uniqKey="Druzd Sitek A" first="Agnieszka" last="Druzd-Sitek">Agnieszka Druzd-Sitek</name>
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<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Maria Sklodowska-Curie Institute – Oncology Center, Warsaw</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Walewski, Jan" sort="Walewski, Jan" uniqKey="Walewski J" first="Jan" last="Walewski">Jan Walewski</name>
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<wicri:regionArea>Maria Sklodowska-Curie Institute – Oncology Center, Warsaw</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Corso, Alessandro" sort="Corso, Alessandro" uniqKey="Corso A" first="Alessandro" last="Corso">Alessandro Corso</name>
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<country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Cocito, Federica" sort="Cocito, Federica" uniqKey="Cocito F" first="Federica" last="Cocito">Federica Cocito</name>
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<country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Vekemans, Marie Christine M" sort="Vekemans, Marie Christine M" uniqKey="Vekemans M" first="Marie-Christine M." last="Vekemans">Marie-Christine M. Vekemans</name>
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<country xml:lang="fr">Belgique</country>
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<placeName><settlement type="city">Bruxelles</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Atilla, Erden" sort="Atilla, Erden" uniqKey="Atilla E" first="Erden" last="Atilla">Erden Atilla</name>
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<country xml:lang="fr">Turquie</country>
<wicri:regionArea>Ankara University Medical School, Ankara</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Beksac, Meral" sort="Beksac, Meral" uniqKey="Beksac M" first="Meral" last="Beksac">Meral Beksac</name>
<affiliation wicri:level="1"><nlm:aff id="A14">Ankara University Medical School, Ankara, Turkey</nlm:aff>
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<author><name sortKey="Leleu, Xavier" sort="Leleu, Xavier" uniqKey="Leleu X" first="Xavier" last="Leleu">Xavier Leleu</name>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Davila, Julio" sort="Davila, Julio" uniqKey="Davila J" first="Julio" last="Davila">Julio Davila</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Hospital Universitario de Salamanca, Salamanca, Spain</nlm:aff>
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</affiliation>
</author>
<author><name sortKey="Badros, Ashraf" sort="Badros, Ashraf" uniqKey="Badros A" first="Ashraf" last="Badros">Ashraf Badros</name>
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</author>
<author><name sortKey="Aneja, Ekta" sort="Aneja, Ekta" uniqKey="Aneja E" first="Ekta" last="Aneja">Ekta Aneja</name>
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</affiliation>
</author>
<author><name sortKey="Abildgaard, Niels" sort="Abildgaard, Niels" uniqKey="Abildgaard N" first="Niels" last="Abildgaard">Niels Abildgaard</name>
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</author>
<author><name sortKey="Kastritis, Efstathios" sort="Kastritis, Efstathios" uniqKey="Kastritis E" first="Efstathios" last="Kastritis">Efstathios Kastritis</name>
<affiliation wicri:level="3"><nlm:aff id="A20">National and Kapodistrian University of Athens, Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>National and Kapodistrian University of Athens, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fantl, Dorotea" sort="Fantl, Dorotea" uniqKey="Fantl D" first="Dorotea" last="Fantl">Dorotea Fantl</name>
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<author><name sortKey="Schutz, Natalia" sort="Schutz, Natalia" uniqKey="Schutz N" first="Natalia" last="Schutz">Natalia Schutz</name>
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<author><name sortKey="Pika, Tomas" sort="Pika, Tomas" uniqKey="Pika T" first="Tomas" last="Pika">Tomas Pika</name>
<affiliation wicri:level="1"><nlm:aff id="A22">University Hospital Olomouc, Olomouc, Czech Republic</nlm:aff>
<country xml:lang="fr">République tchèque</country>
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</author>
<author><name sortKey="Butrym, Aleksandra" sort="Butrym, Aleksandra" uniqKey="Butrym A" first="Aleksandra" last="Butrym">Aleksandra Butrym</name>
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<wicri:regionArea>Wroclaw Medical University, Wroclaw</wicri:regionArea>
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</author>
<author><name sortKey="Olszewska Szopa, Magdalena" sort="Olszewska Szopa, Magdalena" uniqKey="Olszewska Szopa M" first="Magdalena" last="Olszewska-Szopa">Magdalena Olszewska-Szopa</name>
<affiliation wicri:level="1"><nlm:aff id="A23">Wroclaw Medical University, Wroclaw, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Wroclaw Medical University, Wroclaw</wicri:regionArea>
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</author>
<author><name sortKey="Usnarska Zubkiewicz, Lidia" sort="Usnarska Zubkiewicz, Lidia" uniqKey="Usnarska Zubkiewicz L" first="Lidia" last="Usnarska-Zubkiewicz">Lidia Usnarska-Zubkiewicz</name>
<affiliation wicri:level="1"><nlm:aff id="A23">Wroclaw Medical University, Wroclaw, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Wroclaw Medical University, Wroclaw</wicri:regionArea>
<wicri:noRegion>Wroclaw</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Usmani, Saad" sort="Usmani, Saad" uniqKey="Usmani S" first="Saad" last="Usmani">Saad Usmani</name>
<affiliation wicri:level="2"><nlm:aff id="A24">Levine Cancer Institute/Carolinas HealthCare System, Charlotte, NC, USA</nlm:aff>
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<wicri:regionArea>Levine Cancer Institute/Carolinas HealthCare System, Charlotte, NC</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nahi, Hareth" sort="Nahi, Hareth" uniqKey="Nahi H" first="Hareth" last="Nahi">Hareth Nahi</name>
<affiliation wicri:level="3"><nlm:aff id="A25">Karolinska University Hospital, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
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<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chim, Chor S" sort="Chim, Chor S" uniqKey="Chim C" first="Chor S" last="Chim">Chor S. Chim</name>
<affiliation wicri:level="1"><nlm:aff id="A26">Queen Mary Hospital, University of Hong Kong, Hong Kong</nlm:aff>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Queen Mary Hospital, University of Hong Kong</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Shustik, Chaim" sort="Shustik, Chaim" uniqKey="Shustik C" first="Chaim" last="Shustik">Chaim Shustik</name>
<affiliation wicri:level="4"><nlm:aff id="A27">Royal Victoria Hospital, McGill University, Montreal, Canada</nlm:aff>
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<wicri:regionArea>Royal Victoria Hospital, McGill University, Montreal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
<settlement type="city">Montréal</settlement>
</placeName>
<orgName type="university">Université McGill</orgName>
</affiliation>
</author>
<author><name sortKey="Madry, Krzysztof" sort="Madry, Krzysztof" uniqKey="Madry K" first="Krzysztof" last="Madry">Krzysztof Madry</name>
<affiliation wicri:level="1"><nlm:aff id="A28">Medical University, Warsaw, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Medical University, Warsaw</wicri:regionArea>
<wicri:noRegion>Warsaw</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lentzsch, Suzanne" sort="Lentzsch, Suzanne" uniqKey="Lentzsch S" first="Suzanne" last="Lentzsch">Suzanne Lentzsch</name>
<affiliation wicri:level="2"><nlm:aff id="A29">Columbia University Medical Center, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Columbia University Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Swiderska, Alina" sort="Swiderska, Alina" uniqKey="Swiderska A" first="Alina" last="Swiderska">Alina Swiderska</name>
<affiliation wicri:level="1"><nlm:aff id="A30">Provincial Hospital, Zielona Gora, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Provincial Hospital, Zielona Gora</wicri:regionArea>
<wicri:noRegion>Zielona Gora</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Helbig, Grzegorz" sort="Helbig, Grzegorz" uniqKey="Helbig G" first="Grzegorz" last="Helbig">Grzegorz Helbig</name>
<affiliation wicri:level="1"><nlm:aff id="A31">Silesian Medical University, Katowice, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Silesian Medical University, Katowice</wicri:regionArea>
<wicri:noRegion>Katowice</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guzicka Kazimierczak, Renata" sort="Guzicka Kazimierczak, Renata" uniqKey="Guzicka Kazimierczak R" first="Renata" last="Guzicka-Kazimierczak">Renata Guzicka-Kazimierczak</name>
<affiliation wicri:level="1"><nlm:aff id="A32">Pomeranian Medical University, Szczecin, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Pomeranian Medical University, Szczecin</wicri:regionArea>
<wicri:noRegion>Szczecin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lendvai, Nikoletta" sort="Lendvai, Nikoletta" uniqKey="Lendvai N" first="Nikoletta" last="Lendvai">Nikoletta Lendvai</name>
<affiliation wicri:level="2"><nlm:aff id="A33">Memorial Sloan-Kettering Cancer Center, New York, New York, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Memorial Sloan-Kettering Cancer Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Waage, Anders" sort="Waage, Anders" uniqKey="Waage A" first="Anders" last="Waage">Anders Waage</name>
<affiliation wicri:level="3"><nlm:aff id="A34">Norwegian University of Science and Technology, Trondheim, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Norwegian University of Science and Technology, Trondheim</wicri:regionArea>
<placeName><settlement type="city">Trondheim</settlement>
<region type="région" nuts="2">Trøndelag</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Andersen, Kristian T" sort="Andersen, Kristian T" uniqKey="Andersen K" first="Kristian T." last="Andersen">Kristian T. Andersen</name>
<affiliation wicri:level="1"><nlm:aff id="A35">Vejle Hospital, Vejle, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Vejle Hospital, Vejle</wicri:regionArea>
<wicri:noRegion>Vejle</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Murakami, Hirokazu" sort="Murakami, Hirokazu" uniqKey="Murakami H" first="Hirokazu" last="Murakami">Hirokazu Murakami</name>
<affiliation wicri:level="1"><nlm:aff id="A36">Gunma University Graduate School of Health Sciences, Gunma, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Gunma University Graduate School of Health Sciences, Gunma</wicri:regionArea>
<wicri:noRegion>Gunma</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zweegman, Sonja" sort="Zweegman, Sonja" uniqKey="Zweegman S" first="Sonja" last="Zweegman">Sonja Zweegman</name>
<affiliation wicri:level="3"><nlm:aff id="A37">VU University Medical Center, Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>VU University Medical Center, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Castillo, Jorge J" sort="Castillo, Jorge J" uniqKey="Castillo J" first="Jorge J." last="Castillo">Jorge J. Castillo</name>
<affiliation wicri:level="2"><nlm:aff id="A38">Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">American journal of hematology</title>
<idno type="ISSN">0361-8609</idno>
<idno type="eISSN">1096-8652</idno>
<imprint><date when="2016">2016</date>
</imprint>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Antineoplastic Agents (therapeutic use)</term>
<term>Central Nervous System Neoplasms (diagnosis)</term>
<term>Central Nervous System Neoplasms (mortality)</term>
<term>Central Nervous System Neoplasms (secondary)</term>
<term>Central Nervous System Neoplasms (therapy)</term>
<term>Chromosome Aberrations</term>
<term>Combined Modality Therapy</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multiple Myeloma (complications)</term>
<term>Multiple Myeloma (mortality)</term>
<term>Multiple Myeloma (pathology)</term>
<term>Multiple Myeloma (therapy)</term>
<term>Prognosis</term>
<term>Radiotherapy</term>
<term>Retrospective Studies</term>
<term>Survival Analysis</term>
<term>Survival Rate</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Aberrations des chromosomes</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de survie</term>
<term>Antinéoplasiques (usage thérapeutique)</term>
<term>Association thérapeutique</term>
<term>Femelle</term>
<term>Humains</term>
<term>Myélome multiple ()</term>
<term>Myélome multiple (anatomopathologie)</term>
<term>Myélome multiple (mortalité)</term>
<term>Mâle</term>
<term>Pronostic</term>
<term>Radiothérapie</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Taux de survie</term>
<term>Tumeurs du système nerveux central ()</term>
<term>Tumeurs du système nerveux central (diagnostic)</term>
<term>Tumeurs du système nerveux central (mortalité)</term>
<term>Tumeurs du système nerveux central (secondaire)</term>
<term>Études rétrospectives</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Myélome multiple</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Multiple Myeloma</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Central Nervous System Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Tumeurs du système nerveux central</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Central Nervous System Neoplasms</term>
<term>Multiple Myeloma</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Myélome multiple</term>
<term>Tumeurs du système nerveux central</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Multiple Myeloma</term>
</keywords>
<keywords scheme="MESH" qualifier="secondaire" xml:lang="fr"><term>Tumeurs du système nerveux central</term>
</keywords>
<keywords scheme="MESH" qualifier="secondary" xml:lang="en"><term>Central Nervous System Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Central Nervous System Neoplasms</term>
<term>Multiple Myeloma</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antinéoplasiques</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Chromosome Aberrations</term>
<term>Combined Modality Therapy</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prognosis</term>
<term>Radiotherapy</term>
<term>Retrospective Studies</term>
<term>Survival Analysis</term>
<term>Survival Rate</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Aberrations des chromosomes</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de survie</term>
<term>Association thérapeutique</term>
<term>Femelle</term>
<term>Humains</term>
<term>Myélome multiple</term>
<term>Mâle</term>
<term>Pronostic</term>
<term>Radiothérapie</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Taux de survie</term>
<term>Tumeurs du système nerveux central</term>
<term>Études rétrospectives</term>
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<front><div type="abstract" xml:lang="en"><p id="P1">The multicenter retrospective study conducted in 38 centers from 20 countries including 172 adult patients with CNS MM aimed to describe the clinical and pathological characteristics and outcomes of patients with multiple myeloma (MM) involving the central nervous system (CNS). Univariate and multivariate analyses were performed to identify prognostic factors for survival. The median time from MM diagnosis to CNS MM diagnosis was 3 years. Thirty-eight patients (22%) were diagnosed with CNS involvement at the time of initial MM diagnosis and 134 (78%) at relapse/progression. Upon diagnosis of CNS MM, 97% patients received initial therapy for CNS disease, of which 76% received systemic therapy, 36% radiotherapy and 32% intrathecal therapy. After a median follow-up of 3.5 years, the median overall survival (OS) from the onset of CNS involvement for the entire group was 7 months. Untreated and treated patients had median OS of 2 and 8 months, respectively (p<0.001). At least one previous line of therapy for MM before the diagnosis of CNS disease and >1 cytogenetic abnormality detected by FISH were independently associated with worse OS. The median OS for patients with 0, 1 and 2 of these risk factors were 25 months, 5.5 months and 2 months, respectively (p<0.001). Neurological manifestations, not considered chemotherapy-related, observed at any time after initial diagnosis of MM should raise a suspicion of CNS involvement. Although prognosis is generally poor, the survival of previously untreated patients and patients with favorable cytogenetic profile might be prolonged due to systemic treatment and/or radiotherapy.</p>
</div>
</front>
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<li>Argentine</li>
<li>Australie</li>
<li>Belgique</li>
<li>Brésil</li>
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<li>São Paulo</li>
<li>Trondheim</li>
</settlement>
<orgName><li>Université McGill</li>
<li>École de médecine (Université Washington de Saint-Louis)</li>
</orgName>
</list>
<tree><country name="Pologne"><noRegion><name sortKey="Jurczyszyn, Artur" sort="Jurczyszyn, Artur" uniqKey="Jurczyszyn A" first="Artur" last="Jurczyszyn">Artur Jurczyszyn</name>
</noRegion>
<name sortKey="Butrym, Aleksandra" sort="Butrym, Aleksandra" uniqKey="Butrym A" first="Aleksandra" last="Butrym">Aleksandra Butrym</name>
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<name sortKey="Grzasko, Norbert" sort="Grzasko, Norbert" uniqKey="Grzasko N" first="Norbert" last="Grzasko">Norbert Grzasko</name>
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<country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Zweegman, Sonja" sort="Zweegman, Sonja" uniqKey="Zweegman S" first="Sonja" last="Zweegman">Sonja Zweegman</name>
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{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:5502095
   |texte=   Central Nervous System Involvement by Multiple Myeloma: a Multi-Institutional Retrospective Study of 172 Patients in daily clinical practice
}}

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Serveur d'exploration sur les relations entre la France et l'Australie

Central Nervous System Involvement by Multiple Myeloma: a Multi-Institutional Retrospective Study of 172 Patients in daily clinical practice

Central Nervous System Involvement by Multiple Myeloma: a Multi-Institutional Retrospective Study of 172 Patients in daily clinical practice

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Descripteurs français

English descriptors

Abstract

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	Serveur d'exploration sur les relations entre la France et l'Australie
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